Thursday, 9th June 21st Lancefield International Symposium for Streptococci and Streptococcal Diseases 2022

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• Attenuating GBS Hemolysin - Lakshmi Rajagopal

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• Multivalent M-protein based vaccines - James Dale
• Developing minimal peptide epitopes for vaccines for group A streptococcus (GAS) - Michael Good
• The StreptInCor vaccine - Luiza Guilherme
• Dressed for battle; the Group A Lancefield antigen as vaccine target - Nina van Sorge
• The challenges of developing a vaccine against Strep A during a pandemic. - Danilo Gomes Moriel

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• Type I interferons in group A streptococcal infections - Annelies Zinkernagel
• Pneumococcal interaction with the host. - Birgitta Henriques-Normark
• Group B strep colonization and virulence - Kelly Doran

• Increasing antimicrobial resistance in human pathogenic Streptococcus dysgalactiae – of zoonotic origin? - Marte Glambek
• Integrative Reverse Genetic Analysis Identifies Polymorphisms Contributing to Decreased β-Lactam Susceptibility in Streptococcus pyogenes - Stephen B Beres
• Streptococcus pyogenes strains with a recently discovered chimeric penicillin binding protein 2X have decreased beta-lactam antibiotic susceptibility and increased fitness resulting in increased virulence - Randall J Olsen
• Genome-wide transposon mutagenesis screen identifies mutations conferring reduced penicillin susceptibility in group A streptococcus - Luchang Zhu
• Emerging resistance in group B streptococcal infections among neonates in Portugal: 2016-2019 - Elisabete R Martins
• Macrolide-resistance determinants characterization in Streptococcus pyogenes in Barcelona, Spain (2019-2020) - Dàmaris Berbel Palau
• High level resistance to aminoglycosides (HLAR) in Group B Streptococci (GBS): an underestimated aspect - Roberta Creti
• A new integrative and mobilizable element is the major contributor to tetracycline resistance in Streptococcus dysgalactiae subsp equisimilis - Guillem López de Egea Vegas
• Modelling the effect of direct competition on the population-level strain diversity of Group A Streptococcus    - Nefel Tellioglu
• Applying whole genome sequencing to investigating clusters of Streptococcus pyogenes: experiences from England - Juliana Coelho
• Streptococcal carriage and infection epidemiology and risk factors in The Gambia: a longitudinal household cohort study - Edwin P Armitage
• Emergent Streptococcus pyogenes M1_UK in invasive disease compared to carriage isolates in the Netherlands - Nina M van Sorge
• Emergence of an invasive multidrug-resistant emm93.0 Streptococcus pyogenes strain harboring a novel genomic island Israel 2017-2019 - Merav Ron
• The changing epidemiology of invasive group A Streptococcus infections in Israel during the COVID-19 pandemic – Concurrent emergence and expansion of emm74.0 and emm77.0 - Merav Ron
• Throat as portal of entry in invasive Group A Streptococcal disease: a prospective 2-year study in two health districts, Finland - Ville Kaila
• Population Structure of an Emergent Group A Streptococcus M1_UK Clone in Canada - Walter Demczuk
• Sequential real-time PCR assay for emm typing isolates from outbreaks of Group A Streptococcal (GAS) disease in nursing homes in the United States - Srinivasan Velusamy
• Clinical and molecular epidemiology of group A streptococcal carriage and invasive disease in the Netherlands, 2009-2019 - Lidewij W. Rümke
• iGAS clusters linked to elderly care in England – a perspective from the reference laboratory - Bruno Pichon
• High resolution typing of Streptococcus pyogenes using a novel whole genome multilocus sequence typing (wgMLST) schema - Ana Friães
• Epidemiology of aha strep a samples: an afrostrep follow-up study. - Kélin C Engel
• Allele-specific PCR (ASPCR) to distinguish the new S. pyogenes lineage M1_UK from M1_globa - Xiangyun Zhi
• Typical streptococcus - a journey through the genus - Andreas Itzek
• Epidemiology of antibiotic resistance in invasive non-beta-hemolytic streptococci, results form a French national survey in 2021 - Céline Plainvert
• Analysis of emerging invasive group B streptococcus serotype VIII in Alberta, Canada - Gregory J Tyrrell
• Group B Streptococcus (GBS) invasive infections among non-pregnant adults in Belgium, 2018: bacteriological and clinical characteristics. - Rosalie Sacheli
• Invasive group-B streptococcal infections in Germany - Andreas Itzek
• Genomic investigation of Group B Streptococcus causing recurrent infections in infants in the UK - Elita Jauneikaite
• Group B streptococcal bacteraemia: changing trends in a tropical region of Australia - Pirathaban . Sivabalan
• Characterization of Group B Streptococcus strains isolated from neonatal invasive diseases in Belgium, 2018. - Rosalie Sacheli
• Comparison of contemporary colonizing and invasive GBS isolates among non-pregnant adults in Portugal - Elisabete R Martins
• Evaluation of Whole-Genome Sequencing combined with a bioinformatics tool for the complete characterization of Streptococcus agalactiae infection - Sabrina Egrek
• Whole genome sequencing of Group B Streptococci (GBS) strains isolated from mother-infant pairs in four cases of late-onset disease - Roberta Creti
• GBS – Not only a pathogen for neonates - Birger Trollfors
• Invasive infections caused by Streptococcus agalactiae in children up to one year of age – data of the National Reference Laboratory for Streptococcal Infections, Czech Republic, 2003-2020 - Sandra Vohrnova
• A microtitre assay for rapid Group B streptococcus (GBS) serotyping - Karen Broughton
• Characterization of Group B Streptococci (GBS) strains evading molecular diagnostics by chromosomal deletions of the region encoding the cfb gene. - Roberta Creti
• Evaluating clinical scoring systems and rapid diagnostic tests for the diagnosis of Group A Streptococcal pharyngitis in Gambian children - Edwin P Armitage
• Histopathology in necrotizing soft tissue infections. A retrospective cohort study. - Ingunn Margareetta Gundersen
• Development of a point of care test for maternal carriage intrapartum of Group B Streptococcus - Emelie E.C Alsheim
• Time to blood culture positivity in bloodstream infections with Streptococcus dysgalactiae - Anna Bläckberg
• Immunotherapy with antibodies to the conserved region of the M protein and a streptococcal superantigen cooperatively resolve toxic shock-like syndrome in HLA humanized mice - Manisha Pandey
• Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models - Helena Bergsten
• Protocol for a controlled human infection of penicillin against Streptococcus pyogenes: a double-blinded, placebo controlled, randomised trial in healthy adult volunteers (the CHIPS trial) - Thel K Hla
• Not just a biotech tool: role of CRISPR-Cas in the evolution of M1 Streptococcus pyogenes - Edmondo Campisi

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• Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by horizontally-acquired ECF transporter S component - Kalindu M. D. Rodrigo
• Invasive group A streptococcal disease in pregnant women and young children worldwide; systematic review and meta-analyses - Emma Sherwood
• Identification  of Streptococcus pneumoniae cases in hospital settings by ads on complimentary PCR based assays - Vivek Sagar
• Time to negative throat culture from commencement of oral antibiotics for group A Streptococcus infection: systematic review and meta-analysis - Theresa Lamagni
• Penicillin-resistant Group B Streptococcus (PRGBS) isolated from a patient in England. - Derren R Ready
• Identification of novel mobile genetic element associated with resistance to macrolide and lincosamide in group G streptococci - Alexandra G. Kireeva
• Analysis of emm-type specific density and diversity informs next generation Strep A laboratory surveillance - Janessa L Pickering
• Emergence of emm 77.0 group A Streptococcus (GAS) in marginalised populations in South West (SW) England. - Derren Ready
• Streptococcus A diseases data linkage in Victoria (Straddle-Vic) - Katherine B Gibney
• Group A Streptococcus (GAS) pharyngitis incidence has decreased during the COVID-19 pandemic - Ami B Patel
• ‘Strep A Detectives’: The application of environmental health assessment strategies to detect Streptococcus pyogenes in Kimberley school classrooms. - Stephanie L Enkel
• See, Treat, Prevent (SToP) Skin Infections in Remote Kimberley Communities:  A Qualitative Analysis  - Tracy McRae
• The epidemiology of superficial Streptococcal A (skin and throat) infections in Australia: a systematic review. - Sophie Wiegele
• Risk factors for group A streptococcal pharyngitis and skin infections - Julie Bennett
• Streptococcus Viridans isolated from blood cultures in Ugandan infants in 2021 : an update from the PROGRESS study - Lauren Hookham
• SEROTYPE DISTRIBUTION, ANTIBIOTIC RESISTANCE AND SURFACE PROTEINS OF STREPTOCOCCUS AGALACTIAE FROM ADULTS, ITALY, YEARS 2015-2019. - Monica Imperi
• Distribution of sspB1 and sspB1a among clonal complex of GBS human strains - Eugenia Kuleshevich
• qPCR enhances detection of Strep A in skin and throat specimens from children at higher risk of disease - Bernadette Wong
• Qualitative assessment of healthy volunteers receiving subcutaneous infusions of high-dose benzathine penicillin G (SCIP) provides insights into design of late phase clinical studies. - Stephanie L Enkel
• The non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase GapN is a potential new drug target in Streptococcus pyogenes - Philip Eisenberg
• Neurodegenerative disease treatment drug PBT2 breaks intrinsic polymyxin resistance in Gram-positive bacteria   - David MP De Oliveira
• Invasive pyogenic streptococcal and SARS-CoV-2 infection in England during the COVID-19 pandemic - Theresa Lamagni

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• Absence of IFNg-promoting T-cell epitopes within the group A streptococcus M1 protein results in non-protective germinal center responses - Jenny Persson
• Group B Streptococcus hyaluronidase inhibits TLR2/4 signaling to induce IL-10-dependent immune suppression during pregnancy associated infections - Michelle Coleman
• Investigating influenza-group A streptococcal coinfection - Jonathan Jacobson
• The disease potential consequences of, and barriers to, acquisition of the mobile genetic element RD2 by the group A Streptococcus. - Roshika Roshika

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• Emergence of successful group A streptococcal lineages - Claire Turner
• Evolution of Streptococcus pyogenes genotypes exposes plasticity of non-mobile related accessory genes - Magnus M Jespersen
• Core-genome multilocus sequence typing (cgMLST) of Streptococcus pyogenes reveals an increasing prevalence of the M1_UK clone among invasive disease in Portugal (2016-2019) - Ana Friães
• Recent Streptococcus pyogenes emm type changes from cases of invasive disease in Alberta Canada.  - Gregory J Tyrrell

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• Biomarkers in necrotizing soft tissue infections - Laura Marcela Palma Medina
• Endopeptidase PepO as a potential marker for the identification of invasive group A Streptococcus - Yong An Shi
• The performance of a rapid molecular point-of-care test for Strep A pharyngitis in remote-living children at high risk of acute rheumatic fever - Dylan D Barth
• Patient guided quantitative profiling of the Streptococcal antigen-ome - Sounak Chowdhury

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• Streptococcus dysgalactiae – just one small Strep for mankind? - Oddvar Oppegaard
• Differences in disease presentation between Streptococcus dysgalactiae subspecies equisimilis (SDSE) lineages causing human infections - Marcos D Pinho
• Transmission routes of invasive streptococcal disease - Mark van der Linden
• Antimicrobial efficiency of antisense peptide nucleic acids (PNAs) in Streptococcus pneumoniae - Corina Abt

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• Shorter treatment regimen for pharyngotonsillitis - Katarina Hedin
• The Effect of a Prospective Vaccine Against Group A Streptococcus on Antibiotic Consumption for Pharyngitis - Jeffrey Cannon
• Antibiotic susceptibility profiles of Streptococcus pyogenes isolated from invasive and non-invasive infections in a low-resourced setting:  Findings from the AFROStrep Study - Kimona Rampersadh
• Emergence of erythromycin resistant invasive group A Streptococcus in West Virginia, United States - Slawomir Lukomski

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• Beta-hemolytic GBS pigment - properties and function in coagulation and inflammation - Nikolai Siemens
• Group B Streptococcus recurrent neonatal invasive infections: a retrospective study between 2007 and 2020 in France - Asmaa Tazi
• Group B Streptococcus triggers hyper-inflammation in the diabetic wound environment - Rebecca Keogh
• Connectivity and evolution of virulence gene regulation in Group B Streptococcus - Arnaud FIRON